Major Depressive Disorder

Delaware Valley Wellness Center -  - Ketamine Infusion Therapy

Delaware Valley Wellness Center

Ketamine Infusion Therapy & Mental Health Clinic located in Voorhees, NJ, Philadelphia, PA and Delaware

About 7% of American adults experience major depression every year, and one-third of them won’t find relief from antidepressant medications, even after four different trials of medication. Angela Jones, MD, and the team at Delaware Valley Wellness Center have an effective and safe solution: ketamine infusions. Ketamine can improve your depression within hours of your first ketamine infusion, even if you’re treatment resistant. To learn more about ketamine, call the office in Voorhees, NJ, Philadelphia, PA and Delaware, or complete the online questionnaire.

Major Depressive Disorder Q & A

What is major depressive disorder?

Depression causes symptoms ranging from mild to severe. Major depressive disorder, once called clinical depression, represents the most severe type of depression.

Doctors diagnose major depressive disorder when you have at least five of the following symptoms during a two-week period:

  • Depressed mood most of the day and nearly every day
  • Significantly diminished interest in all or almost all activities
  • Significant weight loss (when you’re not dieting) or weight gain
  • Lack of physical activity
  • Fatigue nearly every day
  • Feeling worthless nearly every day
  • Difficulty thinking or making decisions nearly every day
  • Recurring suicidal thoughts with or without a plan to commit suicide

The symptoms of major depressive disorder are severe enough to interfere with your ability to socialize, go to work, or live your daily life.

What is treatment-resistant depression?

Treatment-resistant depression, or treatment-refractory depression, occurs when you take antidepressants but your symptoms don’t improve. Most patients go through a trial-and-error period, starting with one antidepressant at a specific dose, then their doctor changes the dose or medication if they fail to respond.

This type of trial-and-error is common because there are many types of antidepressants and patients respond differently to each one, depending on their metabolism and genetic makeup. If you go through at least two medication trials and your symptoms still haven’t improved, chances are you have treatment-resistant depression.

Unfortunately, treatment-resistant depression is common. About one-third of all patients with depression fail to respond after four trials of antidepressants. If you’re treatment resistant, it’s time to call Delaware Valley Wellness Center and explore the benefits of ketamine infusions.

How do ketamine infusions treat major depressive disorder?

Ketamine is an FDA-approved anesthetic medication that’s safely used during surgery for patients ranging from 3-month-old babies through senior adults. When ketamine is delivered in a low, sub-aesthetic dose, it doesn’t cause anesthesia. Instead, it directly impacts glutamate, a brain chemical involved in mood regulation.

As ketamine balances levels of glutamate, and regenerates nerve connections, symptoms of depression usually  improve. Your symptoms often improve very quickly, typically within hours of your first intravenous (IV) ketamine infusion.

Ketamine is also effective for patients with treatment-resistant depression. About 70-80% of patients who were refractory to treatment find that their symptoms improve after a ketamine infusion.

Although your first ketamine treatment produces results, the doctors at Delaware Valley Wellness Center recommend a series of six treatments over the course of two weeks. This regimen produces long-lasting results that require only occasional maintenance treatments.

You don’t need to continue suffering from major depressive disorder or treatment-resistant depression. Call Delaware Valley Wellness Center or complete the online questionnaire.